To describe the experience of five Israeli pediatric epilepsy clinics treating children and adolescents diagnosed as having intractable epilepsy with a regimen of medical cannabis oil.

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From the Department of Neurology, New York University Langone School of Medicine, New York. Address reprint requests to Dr. Friedman at the Department of Neurology, NYU Langone School of Medicine,

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Almost a third of patients with epilepsy have a treatment-resistant form, which is associated with severe morbidity and increased mortality. Cannabis-based treatments for epilepsy have generated much interest, but scientific data are scarce. We aimed to establish whether addition of cannabidiol to existing anti-epileptic regimens would be safe, tolerated, and effi cacious in children and young adults with treatment-resistant epilepsy.

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Cannabinoids and Epilepsy - Evan C. Rosenberg1 & Richard W. Tsien1 & Benjamin J. Whalley2 & Orrin Devinsky3 / The American Society for Experimental NeuroTherapeutics, Inc. 2015

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