Cannabinoids and Epilepsy

1. J Clin Neurosci. 

Synthetic cannabinoids revealing adrenoleukodystrophy.

Fellner A(1), Benninger F(2), Djaldetti R(2).

Author information:

(1)Department of Neurology, Rabin Medical Center, Beilinson Hospital, 39 Jabotinski Street, Petah Tikva 49100, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: Esta dirección de correo electrónico está siendo protegida contra los robots de spam. Necesita tener JavaScript habilitado para poder verlo..
(2)Department of Neurology, Rabin Medical Center, Beilinson Hospital, 39 Jabotinski Street, Petah Tikva 49100, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

We report a 41-year-old man who presented with a first generalized tonic-clonic seizure after recent consumption of a synthetic cannabinoid. MRI showed extensive bilateral, mainly frontal, white matter lesions. Blood analysis for very long chain fatty acids was compatible with adrenoleukodystrophy, and a missense mutation in the ABCD1 gene confirmed the diagnosis. We hypothesize that cannabinoid use might have contributed to metabolic decompensation with subacute worsening of the underlying condition.

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